No cancer transcriptome study has been reported and the correlation of DNA methylation of myopodin (SYNPO2), PAX6, MSH6, RB1, THBS1, PYCARD, TP73, ESR1, GATA5, PMF‐1, CDKN2B and MUS81a (MUS81) with cancer recurrence, progression and/or survival under BCG treatment were detected through candidate gene analysis 97, 98, 99, 100. The gene discussed is PYCARD; the disease is cancer.