Endothelial injury/dysfunction is an essential promoter of the proinflammatory, procoagulant and pro‐proliferative state.9, 10 In case of uremia, high levels of fibrinogen, thrombin‐antithrombin complexes, thrombomodulin, von Willebrand factor, plasminogen activator inhibitor 1 (PAI‐1), factor VII are markers of endothelial dysfunction. This evidence concerns the gene SERPINE1 and endothelial dysfunction.