In the current study, a significant positive correlation between expression of Dab2 and E-cadherin mRNA was observed in pancreatic cancer cell lines, while downregulation of Dab2 expression in the Panc1 cell line was shown to lead to a significant decrease in E-cadherin mRNA and protein expression, suggesting that Dab2 directly or indirectly controls E-cadherin expression. The gene discussed is DAB2; the disease is familial pancreatic carcinoma.