Pancreatic cancer cell lines that express wild-type K-Ras, the COLO357 and BxPC3 cell lines, were found to exhibit higher protein and mRNA levels of Dab2 compared to AsPC1, Panc1 and MiaPaCa2 cell lines, which express a mutant form of the K-Ras protein (Fig. 1a,c). The gene discussed is DAB2; the disease is familial pancreatic carcinoma.