TNF and psoriasis: Immunobiologicals (IBs) can be used alone or, in some cases, concomitantly with methotrexate, and there are five immunobiologicals currently approved for the treatment of psoriasis in Brazil, three of which are anti-TNF drugs (adalimumab, infliximab, and etanercept) and two interleukin inhibitors (ustekinumab and secukinumab).