CCT has been shown to mediate folding of approximately 10% of the eukaryotic proteome including a number of cancer-linked proteins like p5354, tumor suppressor Von Hippel-Lindau55, signal transducer and activator of transcription 3 (STAT3)56, cyclin E57, p21Ras and cyclin B58. The gene discussed is FLVCR2; the disease is cancer.