RB1 and hepatocellular carcinoma: As shown in Fig. 3, the combination treatment produced strong to very strong synergism in a number of TNBC cell lines with intact RB (MDA-MB 231, HS578T, HCC-1187, HCC38, HCC-1806, MFM223), but not in TNBCs with mutant RB (BT 549 and MD-MB-468), providing evidence that this synergistic effect is associated with RB status.