We discovered a recurrent somatic hotspot mutation in the alpha-kinase domain of the ALPK1 gene (p.V1092A) in 7/16 spiradenomas, 2/8 high-grade, and 2/6 low-grade spiradenocarcinomas (Figs. 1 and 2, Supplementary Data 2) from our discovery cohort. The gene discussed is ALPK1; the disease is benign spiradenoma.