NRAS and cancer: Recurrently altered cancer driver genes included CYLD (15 cases [14 cases with protein coding/essential splice site changes, 1 case with a splice region change]), NRAS (p.Q129E, p.Q61K in the same sample), AKT1 (p.E17K in three cases), TP53 (p.E286K, p.G266E, and p.R248Q and indels p.D228Fs*20, p.R209Fs*6), and DNMT3A (p.R556M, p.R320*, E213_splice, E585_splice) (Fig. 1).