Through its inhibition of mitochondrial bioenergetics, Mito-LND induces ROS in lung cancer cells, which results in the oxidation of mitochondrial peroxiredoxin, inactivation of the AKT/mTOR/p70S6K redox signaling axis and autophagic cell death, as summarized in Fig. 7a. The gene discussed is RPS6KB1; the disease is lung carcinoma.