In the initial SLE cohort we identified 6 rare or novel SNV in BLK (BLKR131W rs73663163, BLKR131Q rs144615291, BLKR238Q rs141865425, BLKP307R novel, BLKY350H rs758750492, and BLKR359C rs146505280, and BLKR359C rs146505280) in 14 patients and an additional low-frequency variant BLKA71T (rs55758736, MAF = 0.012) in 5 patients (Fig. 2a and Table 1). This evidence concerns the gene BLK and systemic lupus erythematosus.