BLK was also chosen because multiple common variants tagging BLK (rs2248932, MAF: 0.49; rs2736340, MAF: 038; and rs13277113, MAF: 0.36) have been identified as SLE-predisposing by GWAS (OR = 1.39 [95% CI: 1.28–1.51])14,23,24 and a large scale Immunochip study25. This evidence concerns the gene BLK and systemic lupus erythematosus.