Similar to the phenotypes we observed after conditional PGC-1 deletion in adult RPE, RPE from dry AMD patients are characterized by degradation of mitochondria, accumulation of lysosomes and increased mesenchymal markers (Ferrington et al, 2016; Golestaneh et al, 2016, 2017; Ghosh et al, 2018). This evidence concerns the gene PPARGC1A and dry age related macular degeneration.