In addition, concomitant changes induced by hyperlipemia were seen in APO A1 and Apo B. Indeed, in hypercholesterolemic rats, decreased Apo A1 levels were accompanied by an elevated concentration of Apo B, thus suggesting that diet-induced hyperlipemia in rats is associated with imbalanced regulation of Lipid Transfer Protein System (Table 1). The gene discussed is APOB; the disease is familial hyperlipidemia.