Altogether, the RPPA output obtained after exposure of GBM cells to SI113 showed i) an overall reduction of mTORC1 activity paralleled by ii) a neurosphere-selective mTORC2 down-modulation accompanied by iii) a remarkable decrease in AKT pS473 and SGK1 pS422, mostly in neurospheres, and iv) a reduction of apoptosis-related endpoints. Here, AKT1 is linked to glioblastoma.