In this work we have studied the effect that VRK1 depletion has on the cellular response to olaparib, a drug which is currently used to sensitize tumor cell to ionizing radiation, and facilitates tumor elimination in cells with altered DNA repair pathways, such as those with BRCA1 [17, 18] or ATM [15, 16] mutations. This evidence concerns the gene VRK1 and neoplasm.