It has been reported that HDAC3 inhibition regulates Keap1/Nrf2 in tumor cell lines or type 1 diabetes-associated aortic pathologies, which is through modulating the expression of miR-200a that binds to the 3′-terminal region of the Keap1 mRNA to inhibit its translation [17, 18]. This evidence concerns the gene KEAP1 and type 1 diabetes mellitus.