As shown in Fig. 5a, western blotting analysis of these rate-limiting enzymes showed that 10 μM SORA treatment reduced the OXPHOS expression in HCC-LM3 cells, while it increased the levels of HK2, PFKFB3, and PKM2, which has been reported to be responsible for the SORA resistance [29]. The gene discussed is PFKFB3; the disease is hepatocellular carcinoma.