The H&E staining and IHC staining of PKM2 and GLUT1 also showed there were more cancer cells and neo-vessels, and higher level of PKM2 and GLUT1 (which represented for the glucose uptake levels) expression in the PKM2-OE group, while in the PB2-treated group, the situation was improved (Fig. 3i). Here, SLC2A1 is linked to cancer.