To further evaluate the combined therapeutic effect of AIBP and APOA-I on colon cancer intestinal neoplasia in ApcMin/+ mice, we generated a recombinant protein containing AIBP fused to the C-terminal of full-length APOA-I and linked by peptides Pro-Gly-Ser-Gly-Ser-Gly, which was designated as R-AIBP + APOA-I. Here, NAXE is linked to colonic neoplasm.