PDK4 and neoplasm: On the other hand, the transcriptome analysis revealed the presence of specific splicing variants of some metabolic genes (GLS, MAOA, ADH1C, ADH5, OGDH, SUCLG1, MDH1, MDH2, SMS, ODC1, FARSB, ACADM, PPM1L, PDK4, PDHX, PDHA1, GOT2, ASS1, RARS, OAT, AOC3, HIBADH, DLD, FH, AUH, MUT) in tumors compared to non-tumor samples (Supplementary Figure S6).