CAV1 and pulmonary arterial hypertension: At the same time, treatment of Cav1−/− mice with NOS inhibitor, L-NAME or peroxynitrite scavenger manganese (III) tetrakis (1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP) reversed the PAH phenotype, confirming the critical role of protein nitration in PAH development [147].