Over a 6-month period, the piglets with a shunt from the left brachiocephalic artery to the pulmonary artery developed pulmonary vasculature changes and right ventricular hypertrophy, which correlated with decreased expression of HO-1 in the pulmonary tissue and decreased HO-1 activity in the right ventricle [201]. This evidence concerns the gene HMOX1 and Right ventricular hypertrophy.