In addition to VEGF, MSC-derived secretome contains several other pro-angiogenic factors (basic fibroblast growth factor (bFGF), TGF-β, platelet-derived growth factor (PDGF), angiopoietin-1, placental growth factor (PGF), IL-6, monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), HGF) which showed beneficial effects in MSC-CM-based therapy of ischemic diseases [70]. This evidence concerns the gene EGF and ischemic disease.