In line with these findings, significant increase in total number of IL-10 and TGF-β-producing Tregs were observed in MSC-CM or MSC-Exo-treated activated PB-MNCs as well as in injured tissues and peripheral lymph organs of MSC-Exo-treated mice with autoimmune and chronic inflammatory diseases (multiple sclerosis, inflammatory bowel disease (IBD) and type 1 diabetes mellitus) [49,50,51,52,53,54]. This evidence concerns the gene IL10 and inflammatory bowel disease.