Previous studies have demonstrated that 3,4-dihydroxybenzalactone (0, 6.25, 12.5, 25, 50 μM) from the fruiting body of P. linteus, treated for 24 h inhibited the migratory and the invasive abilities of cancer cells through suppressing the enzymatic activity of MMP-2 and MMP-9, decreasing the activity of PI3K/AKT, MAPKs, and focal adhesion kinase (FAK)/paxillin, influencing EMT/Snail and Slug, and affecting the NF-κB and Nrf2 signaling pathways in human non-small cell lung carcinoma A 549 cells [53]. Here, AKT1 is linked to cancer.