KRAS and colonic neoplasm: Therefore, the results have concluded that ethanolic extracts of P. linteus significantly improved cetuximab resistance in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutant colon cancer through modulating the RAS/MAPK pathways by reducing the phosphorylation of MAPK, ERK1, and ERK2 by decreasing the expression of KRAS and p-p42/44 MAPK to promote apoptosis.