Protein–protein interaction (PPI) analysis has indicated that the DJ-1 and the 14-3-3 proteins play important roles in polysaccharide-treated HepG2 cells with β-actin as a positive control, but whether these proteins can be used for markers of hepatocellular carcinoma (HCC) needs further investigation [38]. This evidence concerns the gene ACTB and hepatocellular carcinoma.