Thus, pseudohypoxic PPGLs would present more efficient DNA repair, resulting in potential chemoresistance.Interestingly, a combined treatment with a PARP inhibitor and temozolomide improved cytotoxicity in vitro, reducing tumor proliferation and metastatic lesions with prolonged overall survival in mice with SDHB-KO allografts [127]. This evidence concerns the gene SDHB and neoplasm.