GPC3 and esophageal adenocarcinoma: In addition, 25% of esophageal adenocarcinomas (2/8) and 26.5% of esophageal squamous cell carcinoma (SCC; (5/19) showed increased expression of GPC3 [25] in contrast to previous studies that reported lower frequencies of positive staining for GPC3 in esophageal SCC.