NFKB1 and obesity due to melanocortin 4 receptor deficiency: Indeed, salicylic acid acts by inhibiting NF-kB, a transcription factor that stimulates the inflammatory responses associated with insulin resistance [38] and increasing the expression of PPARGs (peroxisomal proliferator-activated receptor-ɣ) and adiponectin, an adipokine with an insulin-sensitizing effect that is often reduced in subjects with obesity [39].