An interesting illustration of catecholamine-induced heart damage occurs in stress mediated cardiomyopathy (Takotsubo syndrome); excessive circulating levels of adrenaline elicit a form of cardiac stunning on a cellular level that comprises the signaling switch of the cardiac β2-AR from Gs to Gi proteins, particularly in the apical myocardium where β-AR density is highest [48], consequently impairing inotropy [49]. The gene discussed is ADRB2; the disease is Tako-tsubo cardiomyopathy.