Although CD117 is a sensitively and specifically expressed marker in GISTs, CD117 is not universally expressed in all GISTs; however, it can be expressed in other tumors, such as melanomas, adenoid cystic carcinomas, Merkel cell carcinomas, Kaposi sarcomas, liposarcomas or even leiomyosarcomas (rarely) [9,10,20]. The gene discussed is KIT; the disease is melanoma.