HMOX1 and neurodegenerative disease: With regard to neurodegenerative diseases, in a rodent model of Alzheimer’s disease (AD), e.g., the SAMP8 mouse, 500 mg/kg of curcumin in a five month diet increased HO-1 gene expression, together with regulators of mitochondrial function, e.g., the translocator protein (TSPO) [67].