In β-cells of type-2 diabetics, upregulation of amysin leads to decreased insulin secretion because fusion pore expansion is impaired (Collins et al., 2016), and the Parkinson’s related protein α-synuclein promotes fusion pore dilation in chromaffin cells and neurons (Logan et al., 2017), thus providing evidence for altered fusion pore behavior in human disease. The gene discussed is INS; the disease is type 2 diabetes mellitus.