BRCA1 and ovarian cancer: Approximately 0.2% to 0.5% of women carry a pathogenic BRCA variant.49, 50 This varies by population; in Ashkenazi Jewish women up to 2.5% have a pathogenic BRCA variant and 29% to 41% of ovarian cancer is attributed to one of three BRCA founder variants (c.68_69delAG and c.5266dupC in BRCA1 and c.5946delT in BRCA2) compared to 10% in the overall outbred ovarian cancer population.51 In Iceland, the BRCA2 variant c.999del5 carries an odds ratio (OR) of 20.7 and accounts for 6.0% to 7.9% of ovarian cancer in that country.52