In addition, reduced neuronal degeneration has been observed in transgenic mice endogenously synthesizing n−3 PUFA, and this has been attributed to the high n−3 PUFA levels present, acting via BDNF signaling (Bak et al. 2015), and n−3 PUFA has also been found to bestow a preventive effect associated with prefrontal cortex BDNF reduction in an animal model of schizophrenia induced by ketamine administration (Zugno et al. 2015). Here, BDNF is linked to schizophrenia.