MAPK and CREB signaling abnormalities have been implicated in schizophrenia, since they play a crucial role in a plethora of pathophysiologic processes that are disrupted in schizophrenia, such as neuroinflammation, apoptosis, cell survival, cell growth, and oxidative stress (Crisafulli et al. 2015; Igolkina et al. 2018; Mohammadi et al. 2018a). Here, CREB1 is linked to schizophrenia.