Treatment with melatonin (100 μM) concurrently with HG for 24 h was able to avert HG-caused increase of DRP1 and decrease of MCU (Figure 1), suggesting that melatonin might have protective actions against hyperglycemia-induced changes in mitochondrial fission-fusion dynamics and in decreased mitochondrial Ca2+ buffering capacity. Here, DNM1L is linked to Hyperglycemia.