NFE2L2 and cancer: In a research from the group of Hiratsuka, it was found that procyanidins (condensed tannins) prepared from Cinnamomi cortex extract (CCE) can suppress NRF2-regulated activity and NRF2 expression in human A549 NSCLC cells [270] (see Table 1), an observation confirmed in a later study from the same authors, wherein the treatment of cancer cell lines of different origin with CCE was shown to selectively reduce the NRF2 mRNA levels and suppress cell proliferation only in the presence of NRF2 overexpression [271].