For example, by using high-throughput screening to identify small molecule inhibitors of the NRF2 transcriptional activity at ARE sites, AEM1 was found to broadly impair the expression of NRF2 target genes, leading to growth inhibition and increased chemosensitivity of A549 NSCLC cells in vitro and in vivo [268] (see Table 1). This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.