NFE2L2 and neuroblastoma: Moreover, a direct targeting of the 3′-UTR in the KEAP1 mRNA by the miR-7 was recently demonstrated in neuroblastoma SH-SY5Y cells, where its high expression was seen to increase the NRF2-dependent transcription of the antioxidant genes HMOX1 and GCLM, therefore attenuating methyl-4-phenylpyridinium- (MPP+-) induced toxicity [202].