Similarly, glucose deprivation was also shown to promote NRF2-mediated induction of antioxidant enzymes in both MCF-7 and T47D breast cancer cells, independently from the macroautophagic response elicited by p62 degradation, since the autophagy inhibitor chloroquine could not prevent the expression of NQO1 [255]. The gene discussed is NFE2L2; the disease is breast carcinoma.