NFE2L2 and non-small cell lung carcinoma: It has been also reported that Luteolin, a flavonoid present in food plants and vegetables, can potently inhibit NRF2 in A549 NSCLC cells (see Table 1), increasing their sensitivity to several anticancer drugs [273], an observation that the same group further confirmed in vivo by xenografting A549 cells in athymic nude mice.