In a study from Li and colleagues, the reduced expression of the methyl transferase EZH2 caused a decrease in the trimethylation of lysine 27 on histone H3 (H3K27Me3) in the NRF2 promoter region, repressing NRF2 expression and NSCLC progression both in vitro and in vivo [180]. Here, NFE2L2 is linked to non-small cell lung carcinoma.