Indeed, by using HCT116 colon carcinoma cells, Lu and coworkers showed that Brusatol can suppress the HIF1α accumulation under hypoxia and abrogate the HIF-dependent transactivation of target genes involved in glucose metabolism and angiogenesis, by promoting HIF1α degradation and decreased ROS production in the cytosol and mitochondria [287]. Here, HIF1A is linked to colon carcinoma.