TXNRD1 and lung cancer: Promising results were also obtained in a model of lung cancer since the thioredoxin reductase 1 (TXNRD1) inhibitor Auranofin, a known antirheumatic agent, was found to synergistically enhance the toxicity of TUSC2/Erlotinib, a treatment currently in phase II clinical trials in stage 4 NSCLC patients refractory to other options.