Moreover, when combined with Adriamycin, Wogonin potentiated the inhibitory effect of ADR on tumor growth in NOD/SCID mice xenografted with K562/A02 CML cells, by suppressing the STAT3/NF-κB/NRF2 pathway [321] (see Table 1). Here, NFE2L2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.