Here, Chrysin was found to decrease the mRNA and protein levels of NRF2 and to chemosensitize multi-drug-resistant HCC-derived cells (Bel-7402/ADM) to Doxorubicin, by preventing HO-1 expression due to the downmodulation of the PI3K/AKT/ERK pathways [292] (see Table 1). This evidence concerns the gene HMOX1 and hepatocellular carcinoma.