NFE2L2 and hepatocellular carcinoma: Intriguingly, while earlier studies reported that the AMPK activator AICAR could induce NRF2 and modulate the redox status of HCC cells independently from AMPK function [253], more recent data indicate that in many cancer cells, the AMPK activity is in contrast required for the expression of NRF2-dependent antioxidant genes in response to glucose withdrawal [254].