Importantly, an emerging mechanism of NRF2/KEAP1 epigenetic deregulation in cancer is represented by microRNAs (miRNAs), small noncoding molecules that recognize the 3′-untranslated regions (UTRs) of specific mRNAs and negatively regulate their abundance by translation blocking or forced degradation [182–184] (see Figure 3(e)). Here, NFE2L2 is linked to cancer.