With this respect, the role of NRF2 in tumor growth and Docetaxel sensitivity was investigated in ErbB2-overexpressing ovarian carcinoma SKOV3 cells, wherein the stable NRF2 depletion by RNAi was able to repress NRF2-dependent signaling, leading to cell growth arrest and tumor growth retardation in mouse xenografts. The gene discussed is NFE2L2; the disease is neoplasm.