KEAP1 and ovarian carcinoma: As concerning KEAP1, miR-141 was the first identified miRNA to directly repress its levels in ovarian carcinoma cell lines [187] while the same miRNA was later shown to confer 5-FU resistance in HepG2 cells, an alteration phenocopied by miR-141 mimics and partially reversed by the reintroduction of KEAP1 [197].