Here, siRNAs against NRF2 or Brusatol were found to induce cell death in human (HCT116) and murine (CT26) cell lines, enhancing also the toxicity of Irinotecan, while Brusatol potently abrogated CRC tumor growth in subcutaneously and orthotopically allografted syngeneic mice [290] (see Table 1). The gene discussed is NFE2L2; the disease is colorectal carcinoma.