NFE2L2 and non-small cell lung carcinoma: Later on, Ren and coworkers demonstrated that Brusatol was able to strongly potentiate the cytotoxic effect of Cisplatin in a broad range of cancer cell lines and A549 NSCLC xenograft, by enhancing the ubiquitination of NRF2 and its subsequent degradation [281] (see Table 1).