NFE2L2 and esophageal squamous cell carcinoma: Recently, miR-432-3p was found to positively modulate NRF2 activity by impairing KEAP1 mRNA translation in esophageal squamous cell carcinoma (ESCC), being its overexpression associated to increased Cisplatin resistance, while conversely, its genetic depletion by CRISPR/Cas9 restored the chemosensitivity [198].