NFE2L2 and esophageal squamous cell carcinoma: Interestingly, not only Halofuginone was shown not only to decrease the proliferation of NSCLC-derived A549 and ESCC-derived KYSE70 cells with constitutive NRF2 activation, but also to enhance the efficacy of common anticancer drugs such as Cisplatin and Doxorubicin both in vitro and in vivo [304]. Taken together, these data support the notion that Halofuginone might represent a valid chemosensitizing agent, especially in NRF2-addicted tumors.