On the other hand, the same group further clarified the mechanism by which Wogonin suppressed NRF2 transcription in resistant K562/A02 CML cells, providing evidence that the functional inactivation of NF-κB was fully responsible for the inhibition of the NRF2/ARE pathway. This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.