NFE2L2 and endometrial cancer: Here, in RL95-2 human endometrial cancer cells, the overexpression of miR-148b was shown not only to markedly decrease cell proliferation but also to enhance ROS production, due to the repression of HIF1 and NRF2 expression resulting from EMRP1 (endoplasmic reticulum metalloprotease 1) downregulation [203].