KEAP1 and hepatocellular carcinoma: In one case, the increased levels of phospho-p62 were found to be associated with NRF2 activation in biospecimens derived from 30 HCC patients [217]; in another case, p62 was found to be upregulated in preneoplastic lesions and both necessary/sufficient for HCC induction in mouse models [218], while in the last study, p62 expression elicited by ferroptosis inducers was able to inactivate KEAP1, promoting NRF2 stabilization and transactivation of both NQO1 and HMOX1 genes [219].