In hepatocellular cancer (HCC) cell lines, NRF2 levels were found to be negatively regulated by miR-144, whose ectopic expression enhanced 5-FU cytotoxicity [190] while in neuroblastoma SH-SY5Y cells, the use of 144 mimics induced ROS-dependent apoptosis by decreasing the expression of enzymes involved in GSH synthesis and GSH-dependent ROS scavenging [191]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.