Indeed, an earlier study reported that high levels of p62 were significantly correlated with HER2 overexpression in human breast cancers [220], while a role for p62 in breast carcinogenesis was further evidenced in a recent study wherein p62 was shown to facilitate HER2-dependent mammary tumorigenesis in MMTV-Neu transgenic mice by the activation of multiple pathways, including the NRF2/KEAP1 [221]. This evidence concerns the gene NFE2L2 and breast carcinoma.