Indeed, LOF mutations in KEAP1 gene were, respectively, found in 50% (6/12) or 19% (10/54) of the cancer cell lines or cancer samples analyzed, while loss of heterozygosity at 19p13.2, the genetic locus of KEAP1, occurred at frequencies of 61% and 41% in NSCLC-derived cell lines and tumor tissues, respectively [134]. Here, KEAP1 is linked to neoplasm.