NFE2L2 and oropharyngeal carcinoma: Moreover, aberrant activation of NRF2 target genes (i.e., ABCC1) has been shown to occur in human oropharyngeal carcinoma KB-7D cells due to B-RAF-mediated NRF2 gene transcription and histone acetyl transferase- (HAT-) dependent NRF2 acetylation, promoting Etoposide resistance [238].