MAPK3 and glioblastoma: Later research extended these observations to human glioblastoma, since Chrysin was found to inhibit the proliferation, migration, and invasiveness of glioblastoma cells by decreasing NRF2 nuclear translocation and suppressing the expression of both HO-1 and NQO1. Moreover, while NRF2 shRNA attenuated the observed antitumor effects in several glioblastoma cell lines, Chrysin decreased the phospho-ERK1/2 protein content and inhibited tumor growth in U87 xenografts [293] (see Table 1).