EGFR and head and neck cancer: Replace Cisplatin with Cetuximab. Cetuximab is an IgG1 monoclonal antibody against the EGFR approved by the US Food and Drug Administration in 2006 due to its proven survival benefit (median survival from 29.3 months to 49 months) without increasing the common toxic effects compared to RT alone in locally advanced head and neck cancer (IMCL-9815 trial) [42].