A recent study demonstrates that SVEP1 is a ligand for integrin a9ß1 and mediates cell adhesion protein is composed of 3,571 amino acids having multiple structural domains including Sushi domain, von Willibrand factor type A domain, epidermal growth factor domain, hyaline repeat domain, and pentraxin domains SVEP1 expression detected in the tissues of heart, lung, skeletal tissue, placenta, stomach, intestine, stromal osteogenic tissues (periosteum and bone), and bone marrow mesenchymal stromal cells, endothelial cells, and breast carcinoma cells10. Here, EGF is linked to breast carcinoma.