The inverse patterns of regulation for the hepatic expression of CIDEA (down-regulated) and FSP27β (up-regulated) is robustly amplified with the NAFLD progression (FSP27β/CIDEA ratio ranges from 1.6 ± 0.6 in simple steatosis (HFD mice) to 21 ± 2 in steatohepatitis (2 weeks MCDD mice) and 48 ± 7 with advanced steatohepatitis (7 weeks MCDD mice)). This evidence concerns the gene CIDEA and metabolic dysfunction-associated steatotic liver disease.