PLIN5 and fatty liver disease: Indeed, other important elements in the regulation of lipid droplet synthesis, such as PLIN5 and PNPLA2, are still upregulated in the fatty liver tissue of MCDD mice (after 7 weeks of MCDD: 2.3-fold increase for PLIN5, p = 0.0142; 3.13-fold increase for PNPLA2) and strongly correlate with hepatic steatosis in obese patients (PLIN5: rs = 0.698, p < 0.001, n = 30; PNPLA2, rs = 0.767, p < 0.001, n = 30).