Several of these compounds are in late stage clinical development, specifically polo-like kinase 1 inhibitors, which demonstrated broad activity in both our HTS and in primary patient samples and have been recognized as Innovative Therapy in Leukemia by the FDA; volasertib has been designated an orphan drug and received breakthrough therapy status for the treatment of AML by the FDA55,56. Here, PLK1 is linked to acute myeloid leukemia.