We identified a single NSCLC sample derived from a 39-year-old patient diagnosed with lung squamous cell carcinoma, displaying NUTM1 mRNA outlier expression (Supplementary Fig. 4e) and carrying a NSD3-NUTM1 rearrangement15 (Supplementary Fig. 4f), a chimeric oncoprotein recently identified in NMC patients and associated with BET inhibitor sensitivity35. Here, NSD3 is linked to nut midline carcinoma.