Likewise, ssGSEA analyses based on methylation subtypes determined by unsupervised clustering (Fig. 3c) showed that MYCMAX_01 motif was significantly enriched (p = 0.00132, an empirical phenotype-based permutation test procedure), confirming the functional convergence on MYC pathway in highly methylated subtype in this tumor type (Supplementary Figure 6a). The gene discussed is MYC; the disease is neoplasm.