Our group discovered that miR-195 inhibited the LRP6 expression via binding to the 3′UTR of LRP6 mRNA, downregulated the nuclear translocation of β-catenin, and accordingly repressed the transcription of β-catenin downstream target genes, such as RUNX2 and VEGFa, which in turn caused lowered CRC metastasis. This evidence concerns the gene RUNX2 and colorectal carcinoma.