PGC1α was an indicator of mitochondrial biogenesis and OXPHOS, and had been reported to inhibit the growth of a number of cancers, such as hepatocellular carcinoma, renal cell carcinoma, malignant fibrous histiocytoma, and lung cancer9,16–18. The gene discussed is PPARGC1A; the disease is hereditary clear cell renal cell carcinoma.