The established macrophage-related gene signature includes both protective genes (SCN3A, SEMA6B) and risk-increasing genes (PXDN, CDH6, ANPEP, CCDC37, DPP4, GPNMB, FANCA, NETO2, PRRG1, TMEM26) for predicting the prognosis of glioma patients (Fig. 3). This evidence concerns the gene PXDN and central nervous system cancer.