Others are due to pathological mutations in molecular chaperones that help nascent NFs acquire a correct tertiary structure: this is the case with CMT2F and CMT2L, two CMT subtypes due to dominant mutations in the heat shock protein (HSP)-encoding genes HSPB1 and HSPB8, respectively [97, 98]. Here, HSPB1 is linked to Charcot-Marie-Tooth disease.