NFASC and amyotrophic lateral sclerosis: There is evidence to support this stoichiometric model too (Table 2): transgenic mice overexpressing wild type NF subtypes can mimic strategic mutant versions that impair NF assembly in their ability to develop abnormal neurofilamentous axonal swellings and progressive neuropathy that are highly reminiscent of those found in ALS [72, 76, 84].