During epithelial to mesenchymal (EMT) in HCC, HOTAIR acts as a scaffold to bridge PRC2 and Snail, which suppresses expression of HNF4a (hepatocyte nuclear factor 4, alpha), HNF1a (HNF1 homeobox A) and E-cadherin by Snail-dependent manner (Fig. 1b). Here, SNAI1 is linked to hepatocellular carcinoma.