The fact that HRS cells secrete molecules involved in monocyte differentiation into macrophages (M-CSF and/or GM-CSF) and in immunosuppressive polarization (M2-TAM) (TGF-β and IL-13) supports the hypothesis that tumor cells can differentiate TAMs towards an immunosuppressive phenotype (M2-TAM) [17,73]. Here, TGFB1 is linked to neoplasm.