CNR1 and obesity due to melanocortin 4 receptor deficiency: Among these, TM38837, also recently termed BPR0912, has a negligible impact on brain CB1R when tested in mice, primates, and healthy individuals [130,131,132], and has been shown to decrease body weight in rodents [133,134] and improve the cardiometabolic complications associated with obesity via increasing thermogenesis in white and brown adipose tissues [135].