Similarly, interference of p53 with the interaction of BAX and Ku70, an acetylation-sensitive DNA repair protein, was shown to promote mitochondria-mediated apoptosis in neuroblastoma cells [159]; the involvement of p53 could be demonstrated by transactivation-deficient p53 mutants that were still able to mediate BAX-dependent apoptosis in HDACi-treated p53-null cells due to the transcription-independent activation of BAX. This evidence concerns the gene TP53 and neuroblastoma.