Wolfram et al. (2002) [40] using a PP fruit pulp (250 g/day; 8 weeks) also reported significant decreases in fasting GLU (p < 0.005) of participants with hypercholesterolemia and hyperlipidemia; and INS (p < 0.005) in participants with hypercholesterolemia but not hyperlipidemia (p > 0.05). This evidence concerns the gene INS and hyperlipidemia.