INS and type 2 diabetes mellitus: The results showed that T2DM participants nopal consumption in combination with a high carbohydrate breakfast incurred significant decreases in serum GLU (30 min, 45 min and 1 h; p < 0.01), GLU by Area Under the Curve (AUC reduction 287 ± 30 mmol/L; p < 0.001), with no significant differences reported in serum INS [50].