Next, in order to further investigate whether the gradual increase in HMGA1 expression along with tumor staging and its impact on EEC patients’ survival could be related with a gain in tumor invasiveness, correlations analyses between HMGA1 and HMGA2 expression levels and those of the metalloproteinases MMP2 and MMP9 were performed using TCGA EEC expression data. The gene discussed is HMGA2; the disease is exstrophy-epispadias complex.