Next, in order to further investigate whether the gradual increase in HMGA1 expression along with tumor staging and its impact on EEC patients’ survival could be related with a gain in tumor invasiveness, correlations analyses between HMGA1 and HMGA2 expression levels and those of the metalloproteinases MMP2 and MMP9 were performed using TCGA EEC expression data. This evidence concerns the gene HMGA1 and exstrophy-epispadias complex.