TNFRSF11B and type 1 diabetes mellitus: After 8 weeks of ICA treatment, the levels of serum Ca, OPG, RANKL, and RUNX 2 were increased significantly, and there were significant differences of serum levels of Ca, RUNX2, OPG, and RANKL between T1DM-ICA and T1DM groups (p < 0.01).