As shown in Figure 7, compared with the control group, the RUNX 2 and OPG mRNA were decreased, RANKL mRNA was increased, and the ratio of OPG/RANKL mRNA was decreased in the T1DM group (p < 0.01); after 8 weeks of ICA administration the RUNX 2 and OPG mRNA were increased, RANKL mRNA was decreased, and the ratio of OPG/RANKL mRNA was increased in T1DM-ICA group compared with T1DM group (p < 0.01). The gene discussed is TNFSF11; the disease is type 1 diabetes mellitus.