TNFRSF11B and diabetes mellitus: This was demonstrated by increased BMD, decreased bone turnover markers, decreased bone marrow adipogenesis, increased OPG/RANKL ratio, increased RUNX 2 expression, improved bone architecture, etc. This study demonstrates that the protective mechanism of ICA on diabetes-induced bone loss was that ICA can reduce blood glucose, inhibit bone turnover, suppress bone marrow lipogenesis, and up-regulate OPG/RANKL ratio and RUNX 2 expression.