PARK7 and Parkinson disease: Another zebrafish model of PD was generated by treating the fish with 6-OHDA, and the marine-derived compound 11-dehydrosinulariolide (11-de) increases cytosolic or mitochondrial dj-1 expression, and then activates the downstream Akt/PI3K, p-CREB, and Nrf2/HO-1 pathways [130].