TF and neoplasm: In cancers in general, three major sets of cellular targets for active targeting are considered: cells which overexpress receptors for transferrin, folate, epidermal growth factor or glycoproteins; tumor endothelium overexpressing vascular endothelial growth factor, integrins, vascular cell adhesion molecule-1, or matrix metalloproteinasas; and cells stromal cells that can acquire tumor survival-propagating phenotype [13].